The first option has an elevated hemoglobin A1C. The second one, a normal A1C.
If you're like most people, you chose door number two - large fluctuations of glucose. But according to research, that might be the wrong option.
Just about every research study on the topic of excess glucose fluctuations, or glycemic variability as it is typically called, suggests excess glucose fluctuations are far more damaging to the body than chronically elevated glucose.
Even when the total glucose load is lower, glycemic fluctuations still appear to be more damaging than chronically elevated glucose.
Glycemic variability seems to lead to more oxidative stress, vascular complications, endothelial dysfunction, and cardiovascular issues than does chronically elevated glucose.
Even mood, obesity, and quality of life are associated with glycemic fluctuations.
But that’s not even the worst part.
Excess glycemic variability often occurs well before glucose regulation starts to deteriorate and therefore standard glucose markers, such as fasting glucose and hemoglobin A1C, will be completely normal.
In case you missed that - excess glucose fluctuations precede insulin resistance, are more damaging to the body than chronically elevated glucose, but don’t show up using standard glucose markers.
That’s a huge problem.
How many patients, or even practitioners, have slowly deteriorating metabolic and glucose regulation that could be identified earlier, if only we were looking for it.
If you're like most people, you chose door number two - large fluctuations of glucose. But according to research, that might be the wrong option.
Just about every research study on the topic of excess glucose fluctuations, or glycemic variability as it is typically called, suggests excess glucose fluctuations are far more damaging to the body than chronically elevated glucose.
Even when the total glucose load is lower, glycemic fluctuations still appear to be more damaging than chronically elevated glucose.
Glycemic variability seems to lead to more oxidative stress, vascular complications, endothelial dysfunction, and cardiovascular issues than does chronically elevated glucose.
Even mood, obesity, and quality of life are associated with glycemic fluctuations.
But that’s not even the worst part.
Excess glycemic variability often occurs well before glucose regulation starts to deteriorate and therefore standard glucose markers, such as fasting glucose and hemoglobin A1C, will be completely normal.
In case you missed that - excess glucose fluctuations precede insulin resistance, are more damaging to the body than chronically elevated glucose, but don’t show up using standard glucose markers.
That’s a huge problem.
How many patients, or even practitioners, have slowly deteriorating metabolic and glucose regulation that could be identified earlier, if only we were looking for it.
